環狀RNA（circRNA）是一種閉環的單鏈RNA分子，在細胞中發揮著多種重要作用，如調控轉錄，或者以ceRNA的方式調控miRNA的活性等等。pCE-RB-Mam環狀RNA過表達載體，多克隆位點兩翼高效促進RNA成環剪切的反向重復序列可使插入到多克隆位點中的序列轉錄后成環剪切，從而實現circRNA的過表達。
代表性客戶文章
- Yao Y, Zhou Y, Hua Q. circRNA hsa_circ_0018414 inhibits the progression of LUAD by sponging miR-6807-3p and upregulating DKK1[J]. Molecular therapy. Nucleic acids, 2021, 23: 783.
- Zhou R, Shi L, Shan K, et al. Circular RNA-ZBTB44 regulates the development of choroidal neovascularization[J]. Theranostics, 2020, 10(7): 3293.
- Chen T, Yu Q, Xin L, et al. Circular RNA circC3P1 restrains kidney cancer cell activity by regulating miR‐21/PTEN axis and inactivating PI3K/AKT and NF‐kB pathways[J]. Journal of cellular physiology, 2020, 235(4): 4001-4010.
- Liu Y, Liu H, Li Y, et al. Circular RNA SAMD4A controls adipogenesis in obesity through the miR-138-5p/EZH2 axis[J]. Theranostics, 2020, 10(10): 4705.
- Li J, Li P, Zhang G, et al. CircRNA TADA2A relieves idiopathic pulmonary fibrosis by inhibiting proliferation and activation of fibroblasts[J]. Cell death & disease, 2020, 11(7): 1-15.
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